The major findings of the present study include: (i) activation of α7nAChR with Ani decreases on-site mortality in crush syndrome; (ii) such effect of activating α7nAChR is partially due to decline of serum potassium; (iii) Ani decreases serum potassium through insulin signaling-Na/K-ATPase pathway. Here, CHRNA7 is linked to Crush Syndrome.