Results of this study demonstrated that the beneficial effect of Ani on mortality in crush syndrome was also mediated by activation of α7nAChR, based on the facts that PNU, selective agonist of α7nAChR, has the similar effect to Ani, but α7nAChR deficiency or MLA, selective antagonist of α7nAChR, attenuated such effect of Ani. Here, CHRNA7 is linked to Crush Syndrome.