Likewise, it has been evidenced the TRPV1 downregulation during adipogenesis of preadipocytes as well as on visceral adipose tissue from db/db and ob/ob mice, suggesting that TRPV1 function prevents adipogenesis and consequently obesity (Miller et al., 1996; Neal and Clipstone, 2002) (Table 2). This evidence concerns the gene TRPV1 and obesity due to melanocortin 4 receptor deficiency.