ACHE and Insulin resistance: Similarly, C57BL/6J mice with a high-fat diet treated with galantamine, an acetylcholinesterase (AChE) inhibitor that enhances cholinergic signaling and also acts as a positive allosteric modulator of a7 nAChR, presented reduction on food intake, body weight and abdominal adiposity as well as an improvement on blood glucose, insulin resistance, and hepatic steatosis (Satapathy et al., 2011) (Table 3).