CALB2 and deafness: Previous studies in young and adult ferrets have demonstrated that in response to bilateral deafness there are plastic adaptations in central auditory nuclei, which are reflected as changes in neuronal excitability, modifications in calretinin immunostaining, and synaptic remodeling (Alvarado et al., 2004, 2007a; Fuentes-Santamaría et al., 2005a, 2007a).