RELN and Cognitive impairment: Reelin is also involved in a number of neurodegenerative and neuropsychiatric disorders presenting with cognitive deficits, including schizophrenia (Guidotti et al., 2000; Chen et al., 2002; Fatemi, 2005; Torrey et al., 2005), bipolar disorder (Fatemi et al., 2000; Torrey et al., 2005), depression (Knable et al., 2004; Lussier et al., 2009, 2011, 2013a,b; Fenton et al., 2015), epilepsy (Fournier et al., 2010; Haas and Frotscher, 2010; Dutta et al., 2011) and autism (Fatemi et al., 2005).