It is interesting to note that crossing a transgenic mouse that overexpresses Reelin with an AD mouse model protects from amyloid plaque formation and rescues learning and memory deficits when compared to the AD mice (Pujadas et al., 2014), while decreasing Reelin in AD models accelerates plaque formation and increases tau hyperphosphorylation (Kocherhans et al., 2010). This evidence concerns the gene RELN and Alzheimer disease.