RELN and Alzheimer disease: These findings include reduction of Reelin and Reelin signaling in an AD mouse model (Mota et al., 2014), electrophysiological measures of Reelin and Aβ effects on hippocampal brain slices (Durakoglugil et al., 2009), and behavioral studies in AD mouse models with altered levels of Reelin (Pujadas et al., 2010; Lane-Donovan et al., 2015).