Altered Reelin signaling has been linked to AD through analyses of human brain samples (Herring et al., 2012; Notter and Knuesel, 2013), and animal models connecting Reelin to the processes of amyloid accumulation (Chin et al., 2007; Kocherhans et al., 2010; Pujadas et al., 2014) and to tau phosphorylation (Ohkubo et al., 2003; Herz and Chen, 2006; Kocherhans et al., 2010; Cuchillo-Ibáñez et al., 2013). The gene discussed is MAPT; the disease is Alzheimer disease.