Interestingly, EVs contain several proteins that have relevance to CNS disease, including all major neuropathological hallmarks of neurodegenerative diseases, such as amyloid β peptide and tau/phosphorylated tau for Alzheimer's disease (AD), α-synuclein for PD, and SOD1/mutant SOD1 and TDP-43 for amyotrophic lateral sclerosis (ALS) (Table 3). This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.