Furthermore, hnRNPA2B1 interacts with another RNA-binding protein, TDP-43, whose presence in protein inclusions is a hallmark of ALS and frontotemporal dementia, and with PPIA, a biomarker of ALS and a key regulator of TDP-43 function (Nardo et al., 2011; Lauranzano et al., 2015). The gene discussed is HNRNPA2B1; the disease is amyotrophic lateral sclerosis.