NRF1 and metabolic dysfunction-associated steatohepatitis: The notion is supported by further experiments revealing that inducible knockout of Nrf1 in the mouse liver35 and its gain-of-function (by over-expressing Nrf1-Tg) in the transgenic mice41 cause impaired expression of key genes responsible for glucose and lipid metabolisms, leading to the pathogenesis of NASH and diabetes mellitus, respectively.