Intriguingly, similar expression patterns of Nrf1 were not found in the high-to-medium differentiated HCC concomitantly with focal necrosis (Figs 14c, column #2, and S6b), but the complex lesions appear to be associated with disturbed expression of the putative active ~120-kDa Nrf1α protein (Fig. 14d, lanes #2 C vs P). This evidence concerns the gene NRF1 and hepatocellular carcinoma.