Further comparisons of results measured from HCC samples #1, #5 and #7 revealed that expression of Nrf1 mRNA and its products (particularly of ~120-kDa Nrf1α) is significantly decreased in intermediately-differentiated carcinomas compared to its para-carcinoma tissue (Figs 14c,d and S6a,e,g). The gene discussed is NRF1; the disease is hepatocellular carcinoma.