NRF1 and neoplasm: However, it is of significant importance to note that the basal expression of ARE-driven genes, but not their inducible expression, is crucial for anti-tumour chemoprevention against DMBA + TPA-induced carcinogenesis in additional transgenic mice that express a dominant-negative dnNrf2 factor, which may also inhibit other Nrf/CNC factors (e.g. Nrf1)24.