The prototypic full-length Nrf1α protein arises by alternative splicing of the mRNA enabling translation of the long TCF11 formy47, 48, such that Nrf1α lacks the Neh4L subdomain (aa 242–271, see Fig. 1c) of TCF11, which is rarely expressed in the human cancer cells (unpublished data) and also is not expressed in the mouse30, 31, 45, 46, 54. The gene discussed is NFE2L1; the disease is cancer.