NRF1 and metabolic dysfunction-associated steatohepatitis: Further, tissue-specifically conditional knockout of Nrf1 (by the Cre-loxP system) in the mouse liver, pancreas, brain and bone results in distinct pathologies of non-alcoholic steatohepatitis (NASH) and hepatoma33, 34, Type-2 diabetes37, neurodegeneration38, 39 and reduced bone size40, respectively.