NRF1 and hepatocellular carcinoma: As anticipated, total mRNA expression levels of Nrf1 (including all variants of its transcripts), together with basal and MG132-stimulated amounts of Nrf1α (and its derivates between 140-kDa and 85-kDa), but not of 65-kDa Nrf1β, are significantly diminished to lower levels detected in all five lines of HCC cells than those obtained from the non-cancerous HL7702 cells (Fig. 14a,b).