In a sharp contrast with the poorly-differentiated HCC, highly well-differentiated hepatocellular carcinoma appeared to have considerably sufficient expression of Nrf1 mRNA (Figs 14c, column #7 and S6g), as well as Nrf1α with a slightly faster electrophoretic mobility to ~130-kDa estimated on 8% SDS-PAGE gels, when compared with that of the 140-kDa Nrf1α expressed in the para-carcinoma tissue (Fig. 14d, lanes #7 C vs P). The gene discussed is NRF1; the disease is hepatocellular carcinoma.