NRF1 and neoplasm: However, an eccentric exception is that a medium-to-low differentiated hepatocellular carcinoma (with tumour embolism being in vessels) seemed to give rise to an unexpectedly incremental expression level of Nrf1 mRNA, but not of Nrf1α proteins (Figs 14c,d cf. #4 with #6, & S6d vs f).