BRAF and neoplasm: In contrast to cases harboring only BRAF V600E mutations, simultaneous BRAF and TERT promoter mutations were associated with older age upon diagnosis (p<0.001), larger tumor size (p = 0.011), more advanced TNM stage (p<0.001), and the solid subtype of PTC in contrast to the follicular subtype (p = 0.006) (S2 Table).