The linkage between Efhd2 gene and LOAD is yet to be determined; however, we and others have shown that EFhd2 expression and protein abundance is altered in AD and animal models that mimic the pathophysiology associated with AD (Vega et al., 2008; Tseveleki et al., 2010; Borger et al., 2014). Here, EFHD2 is linked to Alzheimer disease.