In this fashion, we have come to recognize that the highly conserved transcription factor NK2 homeobox 1 (NKX2-1, encoded by NKX2-1; GENE ID 7080; chromosome 14q13), also called thyroid transcription factor 1, or thyroid-specific enhancer binding protein, possesses properties of particular interest for schizophrenia. This evidence concerns the gene NKX2-1 and schizophrenia.