NKX2-1 and schizophrenia: Although speculative, a possible implication of our emphasis on the role of the NKX2-1 transcription factor, not only for brain development, but also in relation to other physiologic defects with embryonic origins (e.g., gut, respiratory system), is that new therapies for diseases associated with those physiological defects may also be of value to patients with schizophrenia.