The evidence that KCNQ1 genetic variations may confer susceptibility for recurrent seizure activity increasing the risk of sudden death is further supported by the description of a pathogenic KCNQ1 variant (p.Leu273Phe) in a family featuring LQTS and epilepsy (Tiron et al., 2015). The gene discussed is KCNQ1; the disease is familial long QT syndrome.