KCa1.1 channels play a role in promoting high neuronal frequency firing which is consistent with their predominant expression in axon and presynaptic terminals of neurons located in brain regions (e.g., hippocampus and cortex) frequently involved in epilepsy (Gu et al., 2007; Martire et al., 2010). The gene discussed is KCNMA1; the disease is epilepsy.