KCNMA1 and idiopathic generalized epilepsy: As far as genes different from KCNMA1, a polymorphism in KCNMB4, named rs398702, was also associated with mTLE in an Irish cohort population (Cavalleri et al., 2007) but the study failed to be replicated (Manna et al., 2013), while a truncation mutation in KCNMB3 (p.Val256TyrfsTer4) affecting synaptic inhibition and thereby increasing neuronal excitability and seizure susceptibility, was associated with idiopathic generalized epilepsy (Hu et al., 2003; Lorenz et al., 2007).