Indeed, CSCs have also been shown to be exquisitely sensitive to inhibitors of G2/M transition regulators, such as PLK1 and Aurora A, compared to the more differentiated cells of the tumour bulk, which in contrast are more sensitive to anti-mitotic drugs4, 16, 17, 18, 19, 20, 21, 22, 41, 42. Here, PLK1 is linked to neoplasm.