Hyperhomocysteinemia can have many explanations and one of the common gene nutrient interactions to be looked at is common polymorphism in the gene of the enzyme 5,10-methylene tetrahydrofolate reductase (MTHFR), known as the MTHFR 677C>T polymorphism, which results in a thermolabile enzyme [18]. Here, MTHFR is linked to hyperhomocysteinemia.