2008). The proband's mother underwent genetic evaluation and does not carry the mutation. Since the proband's father is deceased, we cannot determine whether the proband's mutation is de novo or inherited. While it seems feasible that her sister's early cancer could have been related, we find no reports of leiomyosarcoma in CDH1 mutation carriers and pathology is not available for re‐review. This evidence concerns the gene CDH1 and leiomyosarcoma.