1998). CDH1 mutations have been found in greater than 50% of families with HDGC (Kaurah et al. 2007). In families that met clinical criteria for HDGC, men carrying pathogenic CDH1 mutations were found to have a 70% cumulative risk of developing gastric cancer by age 80, while women have a 56% cumulative risk of developing gastric cancer by age 80 (Hansford et al. 2015). In addition to the risk of diffuse gastric cancer development, women carrying CDH1 mutations have a 42% cumulative risk of developing breast cancer (typically lobular breast cancer) (Hansford et al. 2015). Here, CDH1 is linked to gastric cancer.