MSTN and neoplasm: Furthermore, WCUP decreased the CT-26 cell-derived production of IL-6 and myostatin, by which WCUP-treated CT-26 CM showed less impairment of C2C12 myoblast proliferation and differentiation and prevention of tumor-induced C2C12 myotube wasting, compared with WCUP-untreated control CT-26 CM (Figs 5 and 6).