Recent studies have clearly shown that cullin RING ligase and neddylation pathway, which is required for its activity, are over-activated in various human cancers and targeting CRL via inhibiting neddylation pathway by a small molecule inhibitor MLN4924 is an effective anticancer approach, as demonstrated in both preclinical7, 10, 13, 18 and clinical settings45, 46. This evidence concerns the gene IL31RA and cancer.