MCL-1 is an anti-apoptotic member of the BCL-2 family, while JAK3 is known to play a crucial role in CD8+ T cell proliferation/differentiation [25, 26] and its expression appears deficient in CD8+ T cells from RCC patients, leading to T cell arrest in cell cycle progression, as we previously described [17]. The gene discussed is JAK3; the disease is renal cell carcinoma.