One pediatric case (6%) also revealed the V648I mutation in the human RET oncogene, a rare substitution reported in medullary thyroid carcinoma, a setting in which it was judged to be “non‐transforming” in the light of elegant in silico and in vitro analyses, and this raised some doubts as to whether V648I might represent the driving force behind the tumor 24. Here, RET is linked to medullary thyroid gland carcinoma.