KDM1A and cancer: The increased expression of E-cadherin, a marker of epithelial cells, and the decreased expression of vimentin, a marker of mesenchymal cells, seen in mice treated with TC is consistent with reports that LSD1 is essential for Snai1-mediated transcriptional repression and for maintenance of the silenced state of Snai1 target genes, including E-cadherin, in invasive cancer cells [35], and that chromatin reprogramming during EMT is LSD1-dependent [56].