ADCY5 and Dystonia: The pathogenicity of this change was supported by its absence in control cases and transmission in affected family members shown by cosegregation analysis.2 Subsequently, a novel c.1252C>T (p.R418W) ADCY5 mutations in 2 sporadic cases of childhood‐onset paroxysmal chorea and dystonia was identified.3 Recently, 2 additional kindreds with autosomal‐dominant mode of inheritance (p.R418W and c.2088+1G>A leading to haploinsufficiency)4, 5 and 1 sporadic patient (p.R418W)4 have been reported with a syndrome of chorea and dystonia without paroxysmal episodes.4, 5