Adenylyl cyclase 5 is the major isoform of adenylyl cyclase in the nucleus accumbens.26 In animal studies, neuronal firing frequency in the nucleus accumbens has been shown to control the level of cortical arousal during the sleep‐wake cycle and also pharmacologically stimulated motor activity.27, 28, 29 Therefore, a gain of function in adenylyl cyclase 5 could potentially lead to increased arousal during sleep and increased motor activity in the form of dyskinesia. The gene discussed is ADCY5; the disease is drug-induced dyskinesia.