For instance, nano-low density lipoproteins have been used as drug delivery vehicles for brain tumors [47]; the brain uptake mechanism of ApoE-coated human serum albumin nanoparticles was also studied [48]; while ApoE-modified liposomal nanoparticles have been reported as promising carriers for gene delivery into the brain [49]. The gene discussed is APOE; the disease is brain neoplasm.