Patients with RARS2 mutations manifest multiple different electroclinical phenotypes including generalized tonic–clonic, focal clonic, and myoclonic episodes.2, 6, 7, 8, 9, 10, 11, 12 Our patients presented with infantile spasms, which have not been reported in RARS2 PCH6 previously. The gene discussed is RARS2; the disease is infantile spasms.