Shared and core FOXO‐bound genes were also enriched for pathways involved in several additional aging‐related processes, including chromatin regulation, immune function, and neurodegenerative disease (Parkinson's disease in the shared FOXO targets and Alzheimer's disease in NPC‐specific targets) (Figs 1H and S2E). The gene discussed is NPC1; the disease is early-onset autosomal dominant Alzheimer disease.