There is also some evidence from genetic studies of a role for folate in the development of aggressive PCa, for example, an association of the homozygote TT genotype of the methylenetetrahydrofolate reductase gene (MTHFR C677T) with lower circulating folate concentrations and reduced risk for aggressive PCa [12], [19]. Here, MTHFR is linked to posterior cortical atrophy.