Furthermore, the disrupted fibroblast growth factor (FGF) signalling in the stromal compartment 17, or targeting of other signalling cascades such as hedgehog, IL6, or CXCL12 14, could detrimentally affect the cancer cells by altering the signalling flux of (rather than selectively ablating) key cascades. The gene discussed is CXCL12; the disease is cancer.