To finish, we created a multivariable logistic regression model using the four miRNAs in both primary and replication groups and examined their capability of separating HNF1B-MODY from patients with other types of diabetes (ESM Fig. 3a, b) or only from patients with HNF1A-MODY (ESM Fig. 3c, d). This evidence concerns the gene HNF1B and diabetes mellitus.