Our assumption of extrapancreatic origin of MODY-associated miRNAs is further strengthened by a recent report by Latreille et al, who showed that beta cell secretion of miR-375 does not contribute significantly to its serum levels and does not differ between HNF1A-MODY and type 1 or type 2 diabetes [27]. The gene discussed is HNF1A; the disease is type 2 diabetes mellitus.