IFNG and allergic disease: However, we did observe effects on IFN‐γ (increased) and IL‐4 (decreased) DLN recall cytokine responses, which may be consistent with the suppression of eosinophil responses, in that IL‐4 is known to increase the number of this cell type in the airways and lungs of mice in an antigen‐dependent manner 26, as well as with the anti‐allergy effects noted with ES‐62 and the SMAs in the OVA model 6, 7.