To investigate whether Aβ-induced epigenetic regulation of HMOX1 could be occurred in other cell types, especially in blood-derived cells, we treated human leukemia cells (Jurkat, U937, HL60 and THP-1) with 1 μM oligomeric form of Aβ1–42 for 6 days and then determined DNA methylation level of HMOX1 at the −374 CpG site and the expression of HMOX1 before and after treatment. Here, HMOX1 is linked to leukemia.