SOX7 and hepatocellular carcinoma: In our study, we revealed these following novel findings: (i) Serial passages of the spheres with doxorubicin and sorafenib could enrich CSC populations in vitro; (ii) miR-452 was identified to promote stem-like properties of HCC; (iii) Sox7 was a direct and functionally relevant target of miR-452 in HCC; (iv) Combination of doxorubicin and ATRA efficiently suppressed metastasis formation of miR-452 overexpressed HCC.