CCL2 and colonic neoplasm: Surprisingly, given the role of CCL2 in tumor-associated macrophage chemotaxis [8] and association between CCL2 content and macrophage infiltrate in colonic tumors [22, 24, 26], we did not detect any effect of EPA on macrophage content of either human or mouse tumors, or any significant change in macrophage polarization in MC38 CRC cell tumors from C57BL/6 mice exposed to EPA in the diet.