GRK4 and thyroid cancer: Some of these proteins were previously involved in thyroid cancer, such as: AKAP9, that was rearranged with BRAF in radiation-associated PTC [16], GRK4, that was overexpressed in thyroid nodules [17], EPHA2, that was overexpressed in thyroid cancer [18, 19], LIMK1 that is targeted by an onco-miR (miR-20a) in thyroid cancer cells [20] and AKT2 that was found upregulated in thyroid cancer and involved in transgenic mouse models of thyroid cancer [21–24].