Thus, most of the identified hits are involved in pathways linked to thyroid cancer: SRC family kinases have been previously involved in RET/PTC signal transduction [25] and in thyroid cancer cell viability [26], JNK and p38MAPK have been found to be activated by RET oncogenes [27, 28] and p38MAPK targeting has been described to effectively reduce proliferation of TPC1 cells [29]. The gene discussed is MAPK8; the disease is thyroid cancer.