This bi-specific (antiEpCAM & antiCD3) trifunctional (FCγ Receptors) antibody binds to the epithelial cell adhesion molecule EpCAM, to CD3+T-cells and to macrophages as well as dendritic- and NK cells via Fcγ receptors and leads to an MHC unrestricted killing of EpCAM positive tumor cells without co-stimulation [1]. This evidence concerns the gene EPCAM and neoplasm.