ESR1 and neoplasm: Moreover, SAA positive macrophages were also associated with larger tumor size (rs = 0.225, p = 0.001), higher histological grade (rs = 0.202, p = 0.003), negative estrogen-receptor (rs = −0.252, p < 0.001) and progesterone-receptor statuses (rs = −0.250, p < 0.001), and human epidermal growth factor receptor 2 (HER- 2) overexpression (rs = 0.204, p = 0.003) (Table 1).