The SAA immunoreactivities in tumor cells and macrophage were both positively associated with lymphovascular invasion (rs = 0.193, p = 0.005; rs = 0.228, p < 0.001, respectively), higher lymph node stage (rs = 0.198, p = 0.004; rs = 0.401, p < 0.001, respectively), and more lymph nodes with tumor metastasis (rs =0.191, p = 0.006; rs = 0.387, p < 0.001, respectively). Here, SAA2 is linked to neoplasm.