In the multivariate Cox proportional hazards regression analysis, after adjusting for age, tumor size, grade, lymph node stage and CD68+ macrophage, SAA immunoreactivity in macrophages was proved to be an independent negative prognostic factor for RFS (HR = 2.33, p = 0.046; Table 4), but not for OS (HR = 6.26, p = 0.063; Table 3). This evidence concerns the gene SAA2 and neoplasm.