In addition, B7-H3 is expressed in both RCC cells and tumor vessels and was marked as expressed in RCC vasculatures in some studies as high as 98% [15], which indicates that B7-H3 could act as a potent new cancer vessel-specific carrier to selectively deliver antiangiogenic or vascular-disrupting agents to diseased tissues, minimize any potential side effects, and could help predict the clinical outcome of using different targeted agents in the treatment of RCC. Here, CD276 is linked to renal cell carcinoma.