We showed that overexpression of LAPTM5 induces lysosomal cell death, demonstrated by cathepsin D release from the lysosome into the cytoplasm, as well as impairment of autophagy via lysosomal destabilization in ESCC and NSCLC cells, as was previously observed in NB cells [5]. The gene discussed is CTSD; the disease is non-small cell lung carcinoma.