Furthermore, we have demonstrated that overexpression of LAPTM5 in NB cells induces lysosomal cell death due to lysosomal destabilization, indicated by leakage of lysosomal cathepsin D into the cytosol via lysosomal membrane permeabilization (LMP), as well as by impairment of autophagy degradation [5]. Here, LAPTM5 is linked to neuroblastoma.