LAPTM5 and esophageal squamous cell carcinoma: To test whether overexpression of LAPTM5 can induce cell death in other types of cancer cell lines, as in NB cells [5], LAPTM5 was introduced by adenovirus into KYSE170 and KYSE770 cells (both ESCC cell lines) and NCI-H460 cells (a NSCLC cell line), all of which demonstrate down-regulation of LAPTM5 (Figure 1A and Figure S1).