Unlike 30% of the chronic HBV human carriers susceptible to infection-promoted immune-inflammatory processes of hepatitis, cirrhosis and/or carcinogenesis of the liver, the transgenic mice expressing the entire HBV genome, carrying the HBe or HBV-core protein, or producing infective HBV particles show no increased incidence of HCC and no pathological changes [34][35]. Here, HBE1 is linked to Cirrhosis.