PML and hepatocellular carcinoma: Thus, the consistent spatiotemporal findings of mutual exclusion (Figure 1A) and reciprocal negative interaction (Figure 1B) between HBsAg and PML during the whole course of HBV-induced pathogenesis and HCC development prompted us to investigate whether different biological consequences progress from HBsAgextensivePMLsuppression to HBsAglostPMLre-appearance conditions (Figure 1C).