Nevertheless, given that PML deficiency resulted in altered metabolism from a glycogenotic state to enhanced adipogenesis and even obesity in HBsAg-transgenic mice (Figure 2 and 5), PML could be the long-sought link between chronic HBV-infection and metabolic reprogramming toward HCC development [43][44][45]. This evidence concerns the gene PML and obesity due to melanocortin 4 receptor deficiency.