PML and hepatocellular carcinoma: Since the PML gene of PML+/+HBsAgtg/0 mice was not mutated during the whole HBsAg-induced pathogenesis, spatiotemporal correlations of the restoration of PML with HCC progression and burnt-out steatosis after decline of HBsAg implicated that the late-onset, aggressive, angiogenic HCC in PML+/+HBsAgtg/0 mice might be addicted to PML [30][31].