PML and hepatocellular carcinoma: Consistent with the clinical findings that loss or low levels of PML reflected less aggressive characters in cancer metabolism and better survival [40][41], PML−/−HBsAgtg/0 mice that developed very early-onset fat-accumulating HCC by one year of age lived as long as PML+/+HBsAgtg/0 mice that developed late-onset fat-burning HCC after 1.5 years (Figure 6C).