NFKB1 and glioblastoma: Concurrent constitutive signaling from NF-κB and STAT3 in glioblastoma CSCs regulates expression of a set of genes (NOTCH1, HES5, JAG1, NUMBL, DTX3, DVL3, and RBPJ) that drive activation of Notch signaling, a third CSC-associated pathway (Figure 2) [92].