Expression of the superrepressor form of IκBα (serines 32/36 mutated to alanines, preventing phosphorylation and degradation and leading to decreased NF-κB activity; IκBα-SR) and genetic deletion of IKKβ or RelA in RAS-driven lung tumor and melanoma models strongly suppressed tumor growth [42,43,44]. Here, NFKBIA is linked to melanoma.