Further comparisons revealed a high percentage of miRNAs target NH receptors such as Angiotensin II receptors (AGTRs), Endothelin receptors (EDNRs), Corticotropin-releasing factor receptors (CRHR2), Mineralocorticoid receptor/Nuclear receptor subfamily 3 group C member 2 (NR3C2), and Natriuretic peptide receptors (NPRs), suggesting miRNA modulates NH signaling cascades in HF in part by attenuating the expression of the cognate receptors. The gene discussed is NR3C2; the disease is hydrops fetalis.