NFKB1 and Familial prostate cancer: Because TLR-signaling mediated activation of the NF-κB transcriptional activity in myeloid cells “primes” cells (or provides the “first signal”) through the up-regulation of NLRP3 and pro-IL-1β protein expression [25, 27], the constitutive activation of the NF-κB activity in prostate cancer cells (such as PC-3 cell line) is predicted to “prime” cells for the activation of the NLRP3 inflammasome.