Additionally, mono-allelic deletion of UVRAG is associated with colon cancer progression [10] and altered expression of MAP1LC3 and LAMP2 (Lysosome-associated membrane protein 2), a protein responsible for the final fusion of the autophagosome with lysosomes, is implicated in the development of neuronal and heart diseases as well as cancer [11]. Here, LAMP2 is linked to colonic neoplasm.