However, our observations that the degree of HCMV-GFP infection and the extent of cGAMP production correlated in myeloid cells, and that pDC were not efficiently infected, suggested that in pDC the viral genome did not reach the cytoplasm to trigger cGAS, and instead directly entered the endosomal/lysosomal pathway to trigger TLR9. The gene discussed is TLR9; the disease is infection.