All of these factors are associated with worse prognosis in HF.31,32 The underlying mechanism to these associations has yet to be elucidated, although probably reflects a higher disease severity incorporating several pathophysiological processes such as nutritional deficiencies, inflammatory state, and renal dysfunction.6,33 In our study, RDW values are likely to be partially explained by hemoglobin/hematocrit (both admission and discharge RDW), transferrin saturation (discharge RDW), and by the presence of peripheral edema (discharge RDW). The gene discussed is TF; the disease is Peripheral edema.