This finding was then replicated in the Duke Databank, in which higher RDW was strongly associated with ACM.6 In the ADHF setting the evidence is scarcer, nonetheless in 628 patients hospitalized for ADHF in Spain, a higher RDW at discharge (both continuous and categorical) was significantly associated with increased mortality independently of Hb value or anemia status. The gene discussed is GSTM1; the disease is anemia (phenotype).