GJA1 and sensorineural hearing loss disorder: Several Cx genes, including Cx26, Cx29, Cx30, Cx31, Cx32, Cx30.3, and Cx43, can induce SNHL.42 These Cx gene families are known to be able to form heteromeric gap junction assemblies.43 In this context, digenic inheritance of SNHL involving GJB2 (Cx26) and GJB3 (Cx31) has been strongly supported by functional studies conducted by Liu et al (2009), which demonstrated a direct physical interaction between Cx26 and Cx31, the presence of heteromeric Cx26/Cx31 connexons, and finally co-assembly of two transfected proteins in the same junction plaques in vitro.