ANK1 and sensorineural hearing loss disorder: Structural variations such as large genomic deletions involving ANK1 at chromosome 8p11.2p12 can lead to contiguous syndrome, with SNHL as one of the symptoms.32 However, the G1748S variant of ANK1 was a point mutation, not a structural variation (see Table S4, Supplemental Content, which illustrates depth of coverage of TES).