MGMT and glioblastoma: Of the reported MGMT-regulating miRNAs, miR-181d-5p 1) exert the most potent effect on MGMT expression – modulating both MGMT mRNA degradation and protein degradation 2) is the only MGMT-regulating miRNA that exhibit consistent inverse correlation with MGMT mRNA expression in multiple independent datasets (including the TCGA, CGGA, and the specimen collection), and 3) it is only MGMT-regulating miRNA that predict clinical survival in glioblastoma patients treated with TMZ [15].