As shown in Figure 5A, transfection of the T98G glioblastoma cell line with pre-miR-124-3p, -127-3p, -181d-5p and -409-3p reduced the MGMT mRNA at different extents, the most significant down-modulation being obtained with the pre-miR-181d-5p and -409-3p. The gene discussed is MGMT; the disease is glioblastoma.