Although the molecular genetics of cutaneous melanomas have been investigated in numerous studies [12, 15, 16], the genetic events that lead to the development of CBN, MABN or ACBN are poorly understood and are limited to a few genes [7, 13, 17–20], including BAP1 (BRCA1-binding protein 1), an oncogenic deubiquitinase, which has been found to be mutated in metastatic uveal melanomas and MABNs [21]. Here, BAP1 is linked to cutaneous melanoma.