FANCD2 and Fanconi anemia: Though they occurred at different frequencies, three genes were found mutated in all tumor samples: GNAQ, the histone methyltransferase KMT2C, and the Fanconi anemia group D2 protein FANCD2; the latter two are involved in epigenetic transcriptional activation and the maintenance of chromosomal stability, respectively [23–25] (Figure 3B).