The 3′-untranslated region (3′-UTR) of EGFR was fused downstream of the firefly luciferase gene in a reporter plasmid, and the recombination plasmid was transfected into NSCLC cell lines A549 and H1975 along with an miR-218-5p mimic. This evidence concerns the gene EGFR and non-small cell lung carcinoma.