AFP and metastatic malignant neoplasm in the lymph nodes: Furthermore, the following factors were associated with unfavorable OS, including the lymph node metastasis (HR: 2.704; 95% CI: 1.071-6.825; p=0.035), distant metastasis (HR: 5.323; 95% CI: 2.282-12.418; p=0.000), higher TNM stage (HR: 1.996; 95% CI: 1.409-2.827; p=0.000), and AFP positivity (HR: 2.004; 95% CI: 1.154-3.478; p= 0.014) (Supplementary Table 1, 2).