KLF6 and neoplasm: Significant differences were observed between the fluorescence signals in KLF6 overexpressed mice and those in negative controls at days 28 and 35, and between the fluorescence signals in KLF6 knock-down mice and those in negative controls at days 21, 28 and 35 (P < 0.05; Figure 5E), suggesting that KLF6 exerted significant tumor growth suppression in vivo.