We hypothesize that this apparently contradictory result is due to the effect of other inhibitory receptors; thus, in healthy individuals the inhibitory receptors ILT2 and ILT4 could play a secondary role in the generation of tolerance of DC, while other molecules, like PDL-1, OX-40L, and ICOSL, may play a crucial role in inducing that regulatory phenotype; conversely, in SLE patients, the existence of a function impairment of the receptors mentioned above may highlight the inhibitory effect of ILT2 and ILT4 not observed in healthy controls. This evidence concerns the gene TNFSF4 and systemic lupus erythematosus.