However, DC from SLE patients showed a decrement on its immunogenic capability upon ligation with ILT2 and ILT4, which supports the hypothesis that in healthy subjects the control of DC activity may rely on other inhibitory receptors; in contrast, in SLE patients the function of these inhibitory receptors may be impaired, and then ILT4 function is more evident. The gene discussed is LILRB2; the disease is systemic lupus erythematosus.