AGTR1 and preeclampsia: Angiotensin II 1 type autoantibodies (AT1-AA) are agonists of AT1R that can cause excessive activation [6] by interacting with the second extracellular loop of the AT1R (AT1R-ECII) [7], thereby causing high blood pressure and proteinuria, which are the typical signs and symptoms of preeclampsia in pregnant rats.