Increases in HGF in the tumor microenvironment contribute to this angiogenic switch (Wagatsuma et al. 1998; Abounader and Laterra 2005), while cMET signaling by the cancer cells facilitates invasion and migration away from the hypoxic interior of the tumor, entry into the new and leaky vessels, and metastasis to distant locations (Gastaldi et al. 2010). The gene discussed is HGF; the disease is cancer.