Indeed, obesity-promoted HGF production by fibroblasts, adipocytes, macrophages, and endothelial cells (Sundaram et al. 2013a, 2014b; Casbas-Hernandez et al. 2011, 2013; Mizuno and Nakamura 2013) may be a unique mechanism to increase blood vessel density and alleviate the hypoxia of obese adipose tissue. The gene discussed is HGF; the disease is obesity due to melanocortin 4 receptor deficiency.